Inhibiting Sec61

You can also search for this author in PubMed Google Scholar

The Sec61 translocon is a highly conserved transmembrane channel complex in the endoplasmic reticulum (ER) membrane that is required for the biogenesis of most secreted and membrane proteins, facilitating the translocation or membrane integration of nascent polypeptides.

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

$29.99 / 30 days

cancel any time

Subscribe to this journal

Receive 12 print issues and online access

$189.00 per year

only $15.75 per issue

Rent or buy this article

Get just this article for as long as you need it

$39.95

Prices may be subject to local taxes which are calculated during checkout

doi: https://doi.org/10.1038/d41573-023-00086-w

Itskanov, S. et al. A common mechanism of Sec61 translocon inhibition by small molecules. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01337-y (2023)

Rehan, S. et al. Signal peptide mimicry primes Sec61 for client-selective inhibition. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01326-1 (2023)

Download references

All outstanding talents are warmly welcome to join Nanchang University to contribute yours wisdoms, realize your dreams and seek common development!

Nanchang, Jiangxi, China

Nanchang University

Two-year postdoctoral fellowship on carbon burial in marine sediments at Umeå University, Sweden

Umeå, Sweden

Umeå University (KBC)

Join Us and Create a Bright Future Together!

Shanghai, China

East China University of Science and Technology (ECUST)

Southern University of Science and Technology (SUSTech) is a public research university funded by Shenzhen city. Widely regarded as a pioneer and i...

Shenzhen

Southern University of Science and Technology (SUSTech)

Chinese Academy of Sciences, seeks exceptional, creative scientists to join its faculty.

Shanghai, China

The Institute of Neuroscience,Center for Excellence in Brain Science and Intelligence Technology,CAS